Objective To explore the clinical efficacy of CT guided ¹²⁵I seeds implantation in the treatment of vertebral metastasis of hepatocellular carcinoma. Methods The clinical and imaging data of 16 cases with 23 metastatic tumors were collected. The efficacy was evaluated by Karnofsky Performance Status (KPS) , Numerical Rating Scale (NRS) and ASIA damage classification before and after surgery. The follow-up time were 12 months, local tumor control rate and survival time were observed. Results All of 23 targets were implanted with ¹²⁵I seeds. The prescribed dose was 12000cGy, the gross tumor volume (GTV) was (22.9±21.4)cc, the median number of seeds was 24(5，50), the radioactive activity of seed was 0.8mCi, the D90 were (12399.7±837.4)cGy and (10506.2±427.1)cGy before and after surgery. The KPS and NRS were both improved significantly 3 month later(P<0.001、P<0.001), the neurological function recovery rate was 60% in 3 month, the local tumor control rate was 93.75%, the median survival time were 8 months while the survival rate of 3,6,12 months was 100%、56.2%、12.5%. All patients had no serious complications during follow-up. Conclusion CT guided ¹²⁵I seeds implantation is an effective and safe palliative treatment in vertebral metastasis of hepatocellular carcinoma, which can effectively relive the pain and improve the function of spine.
Key words ¹²⁵I seed; hepatocellular carcinoma; vertebral metastasis