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Chih-Kang Chiang
单位: National Taiwan University Hospital; National Taiwan University College of Medicine 科室: Department of Integrated Diagnostics & Therapeutics; Graduate Institute of Toxicology,
简历:

Toxicology involves three main categories, including descriptive, mechanistic, and regulatory toxicolo-gy. Recently, several food scandals occurred in Taiwan, which inspired me to extendmy research fields into regulatory toxicology. Inmy master thesis “Regulation and Law Enforcement of Food Safety in Taiwan”, I’ve suggested public private partnership and self-regulation should be applied in the food safety regulation (Law School National Chengchi University, 2016). Furthermore, I’ve  published “Reappraisal of Taiwan Food Safety Law: Emphasize on the application of risk analysis model” to connect the world general consensus into Taiwan food safety regulation (Financial and Economic Law Review, 2017).
In addition, I continued my reaserch work at mechanistic toxicology especially in the endoplasmic retic-ulum (ER) stress-related target organ toxicology in the Nephrology and Metabolism. In the past decade, I proved that ER stress involves in the development of renal fibrosis (Mol Med, 2011), radiocontrast- and cis-platin-induced acute kidney injury (AKI) (Toxicol Sci, 2010, Free Radic Biol Med, 2011), impairment of memory performance (PLoS One, 2012), acute pancreatitis-associated lung injury (World J Gastroenterol, 2013), and cytotoxic effect of celecoxib in human urothelial carcinoma (PLoS One, 2012). Based on my pre-vious findings, I further proved (1) the involvement of caspase-12 dependent ER stress-related apoptotic pathway in radiocontrast urografin-induced AKI (Toxicol Appl Pharmacol, 2013), (2) autophagy contributes to aristolochic acid-induced kidney injury (Toxicology, 2013), and (3) induction of ER stress leads to mesan-gial cells apoptosis via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway by Ochratoxin A (Oncotarget, 2016). By using genetic chop knockout mice, we proved that ablation of PERK-eIF2α axis of ER stress through chop deficiency attenuate oxidative stress in renal ischemia-reperfusion AKI and renal fibrosis (Antioxid Redox Signal, 2015, Oncotarget, 2016). We also successfully demonstrated chemical chaperon, 4-phenylbutyrate, can protect ER stress-mediated renal fibrosis in vivo and in vitro (Oncotarget, 2016). Furthermore, end-stage renal disease patients face erythropoietin (EPO) defi-ciency, which results in renal anemia. My international cooperative works suggested the ATF4 disturbed the binding of HIF-2α and C300 to hypoxia response element in the 3’-enhancer of EPO-producing cells (Am J Physiol Cell Physiol, 2013). Currently, we’re focusing on the impact of adaptive unfolding protein response on the progression of AKI to CKD continuum, and disclosing the down regulation of XBP1s will lead to pro-longed tubular cell cycle arrest and secretion of profibrotic and proinflammatory factors. According to our latest finding, ER stress is actually the double-edged sword during myogenesis perturbation in uremic sarco-penia (J Cachexia Sarcopenia Muscle, in Press).
In metabolism-related studies, we disclosed that (1) ATP synthase subunit-β down-regulation aggravates diabetic nephropathy (Sci Rep, 2015), (2) advanced glycation end products (AGEs) activates ER stress sig-naling with compensatory induction of autophagy, which rescues glomerular mesangial cell apoptosis (Sci Rep, 2016), (3) activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation (Oncotarget, 2017), (4) down regulation of heat shock protein 60 by AGEs will lead to islet beta-cell hypertrophy and dysfunction (Oncotarget, 2016), and (5) AGEs also induce skeletal muscle atrophy and dysfunction in diabetic mice (J Pathol, 2016).
Finally, I also participated in the descriptive toxicology by using Risk21 Matrix for the risk assessment (The Way of Toxicity ~ The Hidden Hazard in Our Food, 2016). Invited by Taiwan FDA, I provided my scientific point of view in food safety issues in, (1) prohibiting food import from Japan’s radiation-affected areas, and (2) confirming the maximum residue limit (MRL) of pesticide in tea leaves. I believed the active contribution of my studies not only exploring the truth of toxicology but also helping our society face Taiwan food safety issue positively and reasonably.

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学术任务如下:

日期 时间 会场 Session/主题 角色 姓名 单位
2018-03-28 15:00-15:30 309B会议室

Pre-Congress Course #2 |Diabetic kidney disease Session3

Dialysis for diabetic patients
讲者

Chih-Kang Chiang

National Taiwan University Hospital; National Taiwan University College of Medicine
2018-03-30 09:45-10:15 311B会议室

Subtheme: dialysis Symposium #4.5 |Dialysis in Special Group

Dialysis modality in the Elderly: Choice of 2 evils
讲者

Chih-Kang Chiang

National Taiwan University Hospital; National Taiwan University College of Medicine