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闵力
单位: 首都医科大学附属北京友谊医院 科室: 消化内科
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首都医科大学附属北京友谊医院/国家消化系统疾病临床医学研究中心,消化内科,助理研究员
联系方式:13552652141; minliasir@126.com
 
 
个人简介
         首都医科大学附属北京友谊医院消化内科助理研究员,北京大学分子生物学博士,在Alim Pharm Ther,Cell Death &Disease,Carcinogenesis,FASEB J等杂志上发表SCI论文29篇,其中第一作者9篇,通讯作者4篇;参编Methods in Molecular Biology系列英文学术专著一部(章节第一作者),长期从事肿瘤标记物与人工智能领域转化研究,目前担任中国医药质量监督管理协会临床试验及大数据质量管理分会委员,中国留学人员联谊会医师协会转化医学分会委员,中国微循环学会转化医学分会青年委员,中国抗癌协会整合肿瘤学分会青年委员, SCI杂志Annals of Translational Medicine杂志与Cancer Translational Medicine杂志兼职编委等学术兼职。
 
学术兼职
中国医药质量监督管理协会临床试验与大数据质量管理分会      委员
欧美同学会·中国留学人员联谊会医师协会转化医学分会        委员
中国微循环学会转化医学分会                                青年委员
中国抗癌协会整合肿瘤学分会                                青年委员
《Annals of Translational Medicine》杂志                        兼职编委
《Cancer Translational Medicine》杂志                          兼职编委
 
教育背景
2007 年 9 月-2011 年 7 月   武汉大学    生物学基地班           学士
2011 年 9 月-2016 年 7 月   北京大学    生物化学与分子生物学   博士
2014 年 11月-2015 年 9月   哈佛大学    生物统计与计算生物学   联合培养博士
 
课题项目
1. 2019/01-2020/12北京市医院管理局“青苗”人才计划(QML20180108),12万元,主持,在研
2. 2018/01-2020/12 北京市医院管理局消化内科学科协同发展中心消化专项重点项目子课题(XXZ0201),消化道早癌和癌前疾病专病队列的整合与规范化建设,80万元,主持,在研
3. 2018/01-2020/12国自然青年基金(81702314),MGP参与调控锯齿状路径来源结肠癌进展的机制研究,20万元,主持,在研
4. 2017/04-2019/06北京市优秀人才培养资助“青年骨干个人”(2017000021469G212),4万元,主持,在研
5. 2016/11-2018/11北京友谊医院科研启动基金(yyqdkt2016-18),Asporin蛋白在结直肠癌早期发生中的作用及其机制研究,3万元,主持,在研
6. 2018/01-2020/12北京友谊医院“种子计划”(YYZZ2017A02),3万元,主持,在研
7. 2013/01-2016/08国自然重点项目(81230046) 酪氨酸磷酸酶PRL-3引起染色体不稳定的机制及其在肠癌发生中的作用,290万元,参与,已结题
 
发表论文
通讯作者论文
(1) H Li#, Z Zhang#, L Chen, X Sun, Y Zhao, Q Guo, S Zhu, P Li, L Min*, S Zhang*. Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer. Cell Death Dis, 2019, 10 (2): 109.
(2) Y Yu, S Zhu, P Li, L Min*, S Zhang*. Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract. Cell Death Dis, 9 (10), 961.
(3) J Shen*, M Li, L Min*. HSPB8 promotes cancer cell growth by activating the ERK-CREB pathway and is indicative of a poor prognosis in gastric cancer patients. Oncol Rep, 2018, 39 (1): 2978-2986.
(4) B Cao#, Y Zhao#, Z Zhang, H Li, J Xing, S Guo, X Qiu, S Zhang, L Min*, S Zhu*. Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer. Int J Oncol, 2018, 53 (5), 1857-1868.
 
第一作者论文
(1) L Min, H Xu, J Wang, L Qu, B Jiang, Y Zeng, L Meng, H Jin, C Shou*. N-α-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28β. FEBS Lett, 2013, 587 (11), 1630-1637.
(2) L Min#, Y Zhao#, X Qiu, R Cheng, J Xing, L Shao, S Guo*, S Zhang*. Integrated Analysis Identifies Molecular Signatures and Specific Prognostic Factors for Different Gastric Cancer Subtypes. Transl Oncol, 2017, 10 (1), 99–107.
(3) L Min#, C Zhang#, L Qu, J Huang, L Jiang, J Liu, L Pinello, GC Yuan*, C Shou*. Gene regulatory pattern analysis reveals essential role of core transcriptional factors’ activation in triple-negative breast cancer. Oncotarget, 2017, 8(13): 21938–21953.
(4) L Min, Y Zhao, J Xing, S Zhang*. Letter: NICE referral criteria for lower gastrointestinal alarm features - not ideal but not poor either. Aliment Pharmacol Ther, 2017, 45(8): 1175-1175.
(5) L Min#, C Zhang#, R Ma, X Li, H Yuan, Y Li, R Chen, C Liu, J Guo, L Qu, C Shou*. Overexpression of synuclein-γ predicts lack of benefit from radiotherapy for breast cancer patients. BMC cancer, 2016, 16 (1), 717.
(6) Y Zhao#, L Min#, C Xu, L Shao, S Guo, R Cheng, J Xing, S Zhu, S Zhang*. Construction of Disease-Specific Transcriptional Regulatory Networks Identified Co-activation of Four Gene in Esophageal Squamous Cell Carcinoma. Oncol Rep, 2017, 38 (1): 411-417.
(7) R Ma#, L Min#, D Chen, W Tao, W Ge, Y Wu*. N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta-analysis. Cancer Biomark, 2013, 13 (6), 447-455.
(8) L Min#, D Chen#, L Qu, C Shou*. Tumor necrosis factor-a polymorphisms and colorectal cancer risk: a meta-analysis. PloS ONE, 2014, 9 (1), e85187.
(9) L Min, RL Ma, H Yuan, C Liu, B Dong, C Zhang, Y Zeng, L Wang, J Guo, L Qu, C Shou*. Combined Expression of Metastasis Related Markers Naa10p, SNCG and PRL-3 and its Prognostic Value in Breast Cancer Patients. APJ CP, 2015, 16 (7), 2819-2826.
(10) 闵力,曾妍,寿成超. 乙酰转移酶基因NAA10的生物学功能及其在肿瘤中的作用. 中国生物化学与分子生物学报, 2013, 29 (10): 902-909.
 
其他论文
(1) Y Zeng, L Min, Y Han, L Meng, C Liu, Y Xie, B Dong, L Wang, B Jiang, H Xu, Q Zhuang,  C Zhao, L Qu*, C Shou*. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis. Carcinogenesis, 2014, 35(10): 2244-2253.
(2) C Zhang, Y Han, H Huang, L Min, L Qu, C Shou*. Integrated analysis of expression profiling data identifies three genes in correlation with poor prognosis of triple-negative breast cancer. Int J Oncol, 2014, 44 (6): 2025-2033.
(3) Y He, X Zhang, L Wang, Z Tian, Q Liu, J Yao, Y Liu, C Li, L Min, B Shan*. Detection of cancer-specific mutations in early-stage non-small cell lung cancer using cell-free DNA by targeted sequencing. Int J Oncol, 2016, 49 (6): 2351-2358.
(4) Jie Xing, Li Min, Shengtao Zhu, H Zhang, Y Zhao, H Li, Z Zhang, P Li, S Zhang*. Factors associated with gastric adenocarcinoma and dysplasia in patients with chronic gastritis: a population-based study. Chin J Cancer Res, 2017, 29(3): 341.
(5) L Wang, L Min, Q Guo, J Zhang, H Jiang, S Shao, J Xing, L Yin, J Liu, R Liu*, S Guo*. Profiling microRNA from brain by microarray in a transgenic mouse model of Alzheimer’s disease. BioMed Res Int, 2017, 8030369.
(6) L Sun, L Min, H Zhou, M Li, F Shao*, W Wang*. Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333 (1), 258-266.
(7) X Jia, L Min, S Zhu, Z Huang*, S Zhang*. Loss of Sonic hedgehog gene leads to muscle development disorder and megaesophagus in mice. FASEB J, 2018, in press.
(8) B Cao, L Min, S Zhu, H Shi, S Zhang*. Long-term oncological outcomes of local excision versus radical resection for early colorectal cancer in young patients without preoperative chemoradiotherapy: a population-based propensity matching study. Cancer Med, 2018, 7 (6), 2415-2422.
(9) L Sun, L Min, M Li, F Shao, W Wang*. Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. Brain Res Bulletin, 2018, 142 (1), 304-312.
(10) R Cheng, S Zhu, S Guo, L Min, J Xing, Q Guo, P Li, S Zhang*. Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma. Oncol Rep, 2018, 39 (6), 2575-2583.
(11) S Zhu, L Min, Q Guo, H Li, Y Yu, Y Zong, L Wang, P Li, J Gu, S Zhang*. Transcriptome and methylome profiling in a rat model of irritable bowel syndrome induced by stress. Int J Mol Med, 2018, 42 (5), 2641-2649.
(12) CT Liu, L Min, YJ Wang, P Li, YD Wu, ST Zhang*. shRNA?mediated knockdown of KNTC1 suppresses cell viability and induces apoptosis in esophageal squamous cell carcinoma. Int J Oncol, 2019, 54 (3), 1053-1060.
(13) J Xing, L Min, H Zhang, P Li, W Li, F Lv, Y Wang, Z Zhang, H Li, Q Guo, S Wang, Y Zhao, J Wang, X Shi, A Wang, S Zhu, M Ji, Y Wu, S Zhang*. A nomogram for endoscopic screening in a high esophageal squamous cell cancer risk area: results from a population-based study. Cancer Manag Res, 2019; 11: 431–442.
(14) S Zhu, J Liu, L Min, X Sun, Q Guo, H Li, Z Zhang, Y Zhao, J Gu, S Zhang*. Cadherin Expression Shift Could Well Distinguish Esophageal Squamous Cell Carcinoma from Non-Cancerous Esophageal Tissues. Oncol Res Treat, 2018;41:380-385.
(15) C Zhang, L Qu, S Lian, L Meng, L Min, J Liu, Q Song, L Shen, C Shou*. PRL-3 promotes ubiquitination and degradation of AURKA and colorectal cancer progression via dephosphorylation of FZR1. Cancer Res, 2019, in press.
 
编写专著
(1) L Min, C Shou. Breast Cancer: Methods and Protocols (In Situ Hybridization of Breast Cancer Markers), P53-59. 2016.
 
会议特邀学术报告
(1) 闵力,Naa10p在肿瘤发生发展中的作用,中国病理生理学会第十四届肿瘤, 第十五届免疫专业委员会学术会议,中国杭州,2014年11月3-4日
(2) L Min, Gene Regulatory Network Analysis Identifies Specific Prognostic Genes in Diffuse and Intestinal Gastric Cancer. Asian Pacific Digestive Week 2017 (APDW 2017), HongKong, China, 23-26 September 2017.
(3) L Min, Gene Regulatory Network Identifies NFYA as A Prognostic Factor in Gastric Cancer. Asian Pacific Digestive Week 2018 (APDW 2018), Seoul, South Korean, 15-18 November 2018.
(4) L Min, Evaluation of circulating extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs. International Society for Extracellular Vesicles 2019 Annual Meeting (ISEV2019), Kyoto, Japan, 25-28 April 2019.

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日期 时间 会场 Session/主题 角色 姓名 单位
2019-09-28 14:30-14:40 国际会议厅

海外英文+最佳英文摘要2

Characterization of CHI3L1 as a potential plasma biomarker for endoscopic resectable gastric cancer by SWATH-MS and transcriptome database analysis
讲者

闵力

首都医科大学附属北京友谊医院