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徐敏
单位: 上海生命科学研究院神经所 科室: -
简历:

博士,博士生导师,中国科学院神经科学研究所研究员、神经环路与行为调控研
究组组长。徐敏研究员主要以小鼠为模型研究睡眠-觉醒调控的神经机理,在国际高水平杂志上发表了一系列相关论文,其中以第一作者或共同第一作者发表Neuron(2018)、Nature Neuroscience(2015,2016)、eLife(2016)、PNAS(2014)等;以参与作者发表 Cell(2018)、Nature(2015)、Science(2014)、Nature Neuroscience(2013)等;徐敏研究员实验室有关“神经活动调控睡眠稳态机制”的最新工作于2020年9月在Science杂志发表(通讯作者)。

徐敏研究员的工作揭示了基底前脑和下丘脑多个核团调控睡眠-觉醒的神经机理,其中有关基底前脑的一系列工作(Nature Neuroscience 2015, elife 2016, Science 2020)全面系统的揭示了该脑区控制睡眠-觉醒的神经环路机制。

 

Dr. Min Xu is a principal investigator in the Institute of Neuroscience, Chinese Academy of Sciences. He received his Ph.D. training in neurobiology with Dr. Mu-ming Poo in the Institute of Neuroscience, CAS. He then did postdoctoral research at the University of California, Berkeley \ Howard Hughes Medical Institute with Dr. Yang Dan. Dr. Xu joined the Institute of Neuroscience as a principal investigator in September 2016. His research focuses on understanding the neural mechanisms behind the sleep-wake cycle. By combining electrophysiology, imaging and behavioral methods, Dr. Xu's work provides important insights into the neural circuits of sleep-wake regulation. In particular, his work comprehensively reveales how different types of neurons in the basal forebrain contribute to sleep-wake transition and control sleep homeostasis.

 

实验室网站:http://www.cebsit.cas.cn/yjz/xm_/yjfx/

报告题目:

基底前脑对睡眠觉醒的调控:从神经环路到睡眠稳态

Basal forebrain control of sleep-wake cycle: from neural circuits to sleep homeostasis

 

摘要:

The mammalian basal forebrain (BF) has long been thought to play critical roles in controlling sleep and wakefulness, but the underlying neural mechanisms remain poorly understood. We systematically investigated the neural mechanisms of the BF in controlling the sleep-wake cycle. We examined the BF circuits by recording and optogenetically perturbing the activity of four genetically defined cell types across sleep-wake cycles and comprehensively mapping their local and long-range synaptic connections using optogenetic assisted electrophysiology or virus-mediated circuit tracing. We also examined how BF neural activity controls sleep homeostasis. Using a novel adenosine sensor, we found a neuronal type-specific control of fast adenosine dynamics during the sleep-wake cycle, and uncovered a critical role of the BF glutamatergic neurons in controlling adenosine dynamics and sleep homeostasis, offering new insights into the mechanisms by which neural activity during wakefulness contributes to the increase of sleep pressure. Together, our work reveals the BF neural mechanisms for controlling the sleep-wake cycles.

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学术任务如下:

日期 时间 会场 Session/主题 角色 姓名 单位
2019-10-26 14:00-14:30 一层韩厅

睡眠觉醒神经环路和调控机制

The Basal Forebrain: Neural Circuits for Sleep-Wake Control, and Beyond
讲者

徐敏

上海生命科学研究院神经所