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Lena Lavie
单位: 以色列 科室: -
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Obstructive sleep apnea (OSA), a nightly respiratory condition affects a large segment of the adult population. It is characterized by intermittent hypoxia (IH) resulting in intermittent reductions in blood oxygenation levels and sleep fragmentation, consequently inducing oxidative stress and inflammation as well as sympathetic activation.  In the last two decades, OSA has been shown to be a major risk factor for cardiovascular and cerebrovascular events contributing to increased morbidity and mortality rates. However, not all OSA patients develop cardio/cerbro-vascular disease even if suffering from similar OSA severity.  The basis for these inter-individual responses to a given hypoxic stimulus may result from genetic factors such as variants in transcription factors as HIF and its downstream genes as VEGF and erythropoietin. However, environmental and life style related variables could play a major role as well.

In the current talk, I will briefly describe the nature of injurious mechanisms leading to cardio/cerbro-vascular morbidity, but will mainly focus on protective mechanisms associated with OSA and IH, based on animal and human studies. Specifically, the following topics will be discussed: (1) Endothelial progenitor cells (EPCs) numbers, development of endothelial cell colony forming units (EC-CFUs) and endothelial tube formation in healthy adults exposed to IH and in patients with acute myocardial infarction, with and without OSA. (2), Inter-individual differences in the responses and the mechanisms associated with their expression in healthy young adults exposed to the same stimuli of IH and sustain hypoxia.  (3) The significance of the variations in the individual responses to the same IH stimulus and their potential contribution to the development of coronary collaterals and to cardiovascular outcome.

Understanding individual differences to various forms of hypoxia and the associated molecular pathways can help to identify patients at higher or lower cardiovascular risk. 

 
Key words:  Intermittent hypoxia, endothelial progenitors cells (EPCs), endothelial cell colony forming units (EC-CFUs), tube formation, coronary collaterals


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学术任务如下:

日期 时间 会场 Session/主题 角色 姓名 单位
2019-10-26 13:30-13:55 二层宴会厅3

睡眠呼吸障碍

Pathways linking Obstructive Sleep Apnea and Cardiovascular Disease
讲者

Lena Lavie

以色列