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李爱青
单位: 南方医科大学南方医院 科室: 肾内科
简历:

一、学习经历

  1. 2003.9-2008.6   理学博士,美国俄亥俄州立大学生物化学与分子生物专业,导师:David L. Denlinger  教授(杰出教授,美国科学院院士

  2. 1999.9-2002.6   理学硕士,江西农业大学动物学专业,导师:薛芳森  教授

  3. 1995.9-1999.6   农学学士,江西农业大学植物保护专业

 
二、工作经历

  1. 2010.2- 现在   教授/博导  南方医科大学南方医院肾内科(南方医科大学“高层次人才计划”引进)

  2. 2008.7-2010.1  博士后  美国俄亥俄州立大学医学院细胞与分子神经科学专业,合作导师:Karl Obrietan  教授

  3.  

 
三、承担科研课题情况
1.国家自然科学基金(No. 81270825)慢性肾衰大鼠盐敏感性的中枢RAS调控机制研究, 2013.01-2016.12,70万,项目负责人
2.国家自然科学基金(No. 31201751)基于大气纳米污染物影响的菜粉蝶脑蛋白质组学研究, 2013.01-2015.12,24万,项目负责人
3.广东省高等学校人才引进专项资金项目(粤财教[2010]343号),生物钟的信号转导研究,80万,2010年7月-2013年6月,项目负责人
4.广东省自然科学基金项目博士启动项目(10451051501005757),癫痫海马硬化发生机制的研究, 3万,2010年10月-2012年10月,项目负责人
5.教育部高等学校博士学科点专项科研基金新教师基金(20104433120005),癫痫海马组织苔藓纤维发芽和神经元损伤机制的研究,3.6万,2011年1月-2013年12月,项目负责人
6.南方医科大学南方医院“高层次优秀人才”启动基金项目(2010111502),肾脏与脑的相互作用研究,100万,2010年1月-2012年12月,项目负责人
7.南方医科大学“国家杰出青年科学基金培育计划”(X201005),慢性肾衰盐敏感性的中枢调控机制研究30万,2011年1月-2013年12月,项目负责人
8.广东省自然科学基金研究团队肾脏纤维化的发生发展及其防治(2014A030312014), 300万,2015年1月—2020年1月,核心成员(排名第三)
9.国家自然科学基金重点项目(No. 81130011),Wnt/β-catenin在肾脏纤维化中的作用和机制研究,280万,2012年1月-2016年12月,核心成员 (排名第三)
10.美国俄亥俄州立大学基金项目(No. 501300),癫痫病海马组织的蛋白质组学研究(Proteomic analysis of the epileptic hippocampus),5万美元  2009年1月-2009年12月,项目负责人
 
四、发表的论文

  1. Aiqing Li*, Minzi Qiu, Hongbo Zhou,Tao Wang, Wen Guo*. PTEN, insulin resistance, and cancer. Current Pharmaceutical Design 2017. In press.

  2. Cao W#, Li A#, Li J, Wu C, Cui S, Zhou Z, Liu Y, Wilcox CS, Hou F F*. Reno-cerebral reflex activates renin-angiotensin system promoting oxidative stress and renal damage after ischemia-reperfusion injury. Antioxid Redox Sign. 2017, in press, DOI: 10.1089/ars.2016.6827. (Co-first author)

  3. Hongguo Zhu, LishanTan, YuminLi, JiawenLi, MinziQiu, LanyingLi, MengbiZhang, Min Liang*, AiqingLi*. Increased apoptosis in the paraventricular nucleus mediated by AT1R/Ras/ERK1/2 signaling results in sympathetic hyperactivity and renovascular hypertension in rats after kidney injury. Front. Physiol. 2017, 8:41. 

  4. Min Liang#, Aiqing Li#, Aiju Lou, Xifang Zhang, Youyuan Chen, Lei Yang, Yumin Li, Shenglin Yang, Fan Fan Hou*. Advanced Oxidation Protein Products promote NADPH oxidase–dependent β-cell destruction and dysfunction by a Bcl-2/Bax apoptotic pathway. Laboratory Investigation, 2017, accepted. (Co-first author)

  5. Xuandi Lai, Lishan Tan, Xiulong Deng, Jinbin Liu, Aiqing Li*, Jianyu Liu, and Jianqiang Hu* Coordinatively self-assembled luminescent gold nanoparticles: fluorescence turn-on system for high-efficiency passive tumor imaging. ACS Appl. Mater. Interfaces, 2017, 9 (6), pp 5118–5127.

  6. Shaoling Jiang, Hanchang He, Lishan Tan, Liangliang Wang, Zhengxiu Su, Yufeng Liu, Hongguo Zhu, Menghuan Zhang, Fan Fan Hou & Aiqing Li* Proteomic and phosphoproteomic analysis of renal cortex in a salt-load rat model of advanced kidney damage. Scientific Reports 2016, 6, 35906.

  7. Min Li, Lishan Tan, Liangfeng Tang, Aiqing Li*, Jianqiang Hu. Hydrosoluble 50% N-acetylation thiolated chitosan complexing with cobalt as a pH responsible renal fibrosis targeting drugs. Journal of Biomaterials Science, Polymer Edition, 2016, 27, 972-985.

  8. Yongxiang Chen, Shiqin Lai, Shaoling Jiang, Yan Liu, Chenglin Fu, Aiqing Li*.,Yuyu Chen, Xuandi Lai, Jianqiang Hu. Synthesis and enhanced electrocatalytic properties of Au/Pd/Pt nanohollows. Materials Letters 2015, 157,15-18

  9. Wei Cao#, Aiqing Li#, Liangliang Wang, Zhanmei Zhou, Zhengxiu Su, Wei Bin, Christopher S. Wilcox, and Fan Fan Hou. A Salt-Induced Reno-Cerebral Reflex Activates RAS and Promotes CKD Progression. Journal of the American Society of Nephrology. 2015, 26,1619-1633.  (recommended by F1000) (Co-first author)

  10. Xuandi Lai, Xiumei Feng, Jianqiang Hu, Lishan Tan, Jianyu Liu, Yuyu Chen, Xiulong Deng, Aiqing Li*. A straightforward and effective strategy for controllable synthesis of Ag/Ag2S and Ag/CdS heterojunction nanowires. Journal of Nanoparticle Research 2015, 17,113.

  11. Su Zhengxiu, Hongguo Zhu, Menghuan Zhang, Liangliang Wang, Hanchang He, Shaoling Jiang, Fan Fan Hou, Aiqing Li*. Salt-induced changes in cardiac phosphoproteome in a rat model of chronic renal failure. PLOS ONE 2014, 9(6), e100331. doi:10.1371/journal.pone.0100331  (Featured on Global Medical Discovery as a Key Scientific Article [ISSN 1929-8536, Nov. 18 2014 ] (https://globalmedicaldiscovery.com )) 

  12. Cui Ye, Huan Guo, Menghuan Zhang, Hongguo Zhu, Jianqiang Hu, Xuandi Lai, Aiqing Li*. Synthesis and enhanced electrochemical property of Au-doped cerium phosphate nanowires. Materials Letters 2014, 131, 141-144.

  13. Lai X, Feng X, Zhang M, Hong R, Chen Y, Li A*, Deng X, Hu J. Large-scale synthesis and surface plasmon resonance properties of angled silver/silver homojunction nanowires Journal of Nanoparticle Research 2014,16, 2272.

  14. Hu G., Lai S., Ye C., Li A., Liu J., Lai X., Yu X., Chen X., Fu H. Hu J. A high-performance and well-dispersed Ag–Pd/UCNTs catalyst for aqueous-phase dechlorination of chlorobenzene. Materials Letters 2013, 93, 278–281.

  15. , H., Ye, C., He, H., Hu, J., Hu, G., Li, A.*. Inlaid Nd-substituted bismuth titanate nanoplates for protein immobilization and Nd-controlled electrochemical properties. Biosensors and Bioelectronics 2012, 33, 204-210. 

  16. Li, A., Wang L., Liang M., Zhou Q., Wang G., Hou F. Proteomic approach to understanding the maternal effect in the flesh fly, Sarcophaga bullataEuropean Journal of Entomology 2012, 109, 7-14.

  17. Li, A., Choi, Y. S., Dziema, H., Cao, R., Cho, H. -Y., Jung, Y. -Y., Obreitan, K. Proteomic profiling of the epileptic dentate gyrus. Brain Pathology 2010, 20, 1077-1089.

  18. Li, A., Benoit, J. B., Lopez-Martinez, G., Elnitsky, M. A., Lee, R. E., Denlinger, D. L. Distinct contractile and cytoskeletal protein patterns in the Antarctic midge are elicited by desiccation and rehydration. Proteomics 20099, 2788-2798.  

  19. Lee, B.*, Li, A.*, Hansen, K. F., Cao, R., Yoon, J. H., Obrietan, K. CREB regulates timing and entrainment of the SCN circadian clock. Journal of Biological Rhythms 2010, 25, 410-420. (Co-first author)

  20.  X., Hu, J., Chen, Z., Feng, X., Li, A.* Nanoplated bismuth titanate sub-microspheres for protein immobilization and their corresponding direct electrochemistry and electrocatalysis. Biosensors and Bioelectronics 2009, 24, 3448-3454.  

  21.  J, Feng X, Hu J, Chen X, Li A.* Al3+-directed self-assembly and their electrochemistry properties of three-dimensional dendriform horseradish peroxidase/polyacrylamide/platinum/single-walled carbon nanotube composite film. Biosensors and Bioelectronics 2010, 25, 1186-1192.  

  22. Rinehart, J. P., Li, A., Yocum, G. D., Robich, R. M., Hayward, S. A. L., Denlinger, D. L. Upregulation of heat shock proteins is essential for cold survival during insect diapause. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2007, 104, 11130-11137.

  23. Li, A., Rinehart, J. P., Denlinger, D. L. Neuropeptide like precursor 4 is uniquely expressed during pupal diapause in the flesh fly. Peptides 2009, 30, 518-521.

  24. Li, A., Michaud, M. R., Denlinger, D. L. Rapid elevation of Inos and decreases in abundance of other brain proteins at pupal diapause termination in the flesh fly Sarcophaga crassipalpisBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics 20091794, 663-668. 

  25.  X., Xie, J., Hu, J., Feng, X., Li, A.* EDTA-directed self-assembly and enhanced catalytic properties of sphere-constructed platinum nanochains. Journal of Physics D-Applied Physics 2010, 43, 115403.

  26. Ye, C., Kong, Q., Wu, R., Hu, J., Chen, Z., Li, A.* Synthesis and enhanced electrochemical properties of pod-shaped gold/silica nanoparticles. Material Letters 2010, 64, 1720-1723.

  27. Li, A., Denlinger, D. L. Pupal Cuticle Protein (PCP) is abundant in early adult diapause of the mosquito, Culex pipiensJournal of Medical Entomology 2009, 46, 1382-1386. 

  28. Li, A., Denlinger, D. L. Rapid cold hardening elicits changes in brain protein profiles of the flesh fly, Sarcophaga crassipalpisInsect Molecular Biology 2008, 17, 565-572. (SCI, IF=2.669, Cited: 6)

  29. Li, A., Popova-Butler, A., Dean, D. H., Denlinger, D. L. “Proteomics of the flesh fly brain reveals an abundance of upregulated heat shock proteins during pupal diapause. Journal of Insect Physiology 2007, 53, 385-391.

  30. , A., Xue, F., Hua, A., Tang, J. Photoperiodic clock of diapause termination in Pseudopidorus fasciata (Lepidoptera: Zygaenidae). European Journal of Entomology 2003100, 287-293.

  31. Hu, J., Yu, Y., Guo, H., Chen, Z., Li, A., Feng, X., Xi, B., Hu, G. Sol-gel hydrothermal synthesis and enhanced biosensing properties of nanoplated lanthanum-substituted bismuth titanate microspheres. Journal of Materials Chemistry 2011, 21, 5352-5359.

  32. , R., Li A., Cho, H. Y., Lee, B., Obrietan, K. Mammalian Target of Rapamycin Signaling Modulates Photic Entrainment of the Suprachiasmatic Circadian Clock. Journal of Neuroscience 2010, 30, 6302-6314.

  33. Cao, R., Li A., Cho, H. Y. mTOR signaling in epileptogenesis: too much of a good thing? Journal of Neuroscience 2009, 29, 12372-12373. 

  34. Cheng H. Y. M., Alvares-Saavedra, M., Dziema, H., Choi, Y. S., Li, A., Obrietan, K. Segregation of expression of Period gene homologs in neurons and glia: Possible divergent roles of Period1 and Period2 in the brain. Human Molecular Genetics 2009, 18, 3110-3124. 

  35. Zhou, L., Cao, W., Xie, C., Tian, J., Zhou, Z., Zhou, Q., Zhu, P., Li, A., Liu, Y., Miyata, T., Hou F., Nie J. The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney International 2012, 82, 759-770.

  36. Denlinger, D., Li, A., Rinehart, J. Heat shock proteins are critical for insect winter survival. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology 2007, 146, 151-152.

  37. Xue, F., Spieth, H. R., Li A., Hua A. The role of photoperiod and temperature in determination of summer and winter diapause in the cabbage beetle, Colaphellus bowringi (Coleoptera: Chrysomelidae). Journal of Insect Physiology 200248, 279-286.

  38. Wei, X., Xue, F., Li, A. Photoperiodic clock of diapause induction in Pseudopidorus fasciata (Lepidoptera: Zygaenidae). Journal of Insect Physiology 2001, 47, 1367-1375.

 
 

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日期 时间 会场 Session/主题 角色 姓名 单位 观看PPT视频
2019-09-20 15:50-16:00 第五会场(新闻发布厅A)

口头交流五

中枢肾素前体受体对盐诱导肾损伤调控作用的研究
讲者

李爱青

南方医科大学南方医院