
单位: | 广东医科大学附属医院 科室: 肾内科 |
简历: |
刘 华 锋 个 人 简 历 [7] 蛋白尿所致肾小管损作机制及防治系列研究(编号:2014KTSCX086),2014年广东省教育厅科研平台和项目。第一承担者,2014-20162年,在研。[8] 尿蛋白所致肾小管上皮细胞内自噬泡堆积的深层机制探讨,2011年广东省自然科学基金(NO.S2011010002623), 第一承担者,2011-2013年,在研。[9] 在尿蛋白所致肾小管上皮损伤起关键作用的PKC同工酶的筛选。2009年广东省高等学校高层次人才项目,第一承担者,2009-2011年,已结题。 [10] 蛋白激酶C同功酶在尿蛋白诱导肾小管上皮损伤中的作用,2008年广东省自然科学基金(编号:8152402301000014), 第一承担者,2008-2010年,已结题。 [11] FSGS患者血清对足细胞凋亡及粘附功能的影响,2007年广东省自然科学基金(NO:7009939), 第一承担者,2007-2010年,已结题。 [12] 免疫抑制剂对HBV感染肾病患者肝炎活化危险性及预防. 2006年广东省科技计划项目(NO: 2006b36005020),2007-2010年,已结题。 [13] 筛选一个可防治蛋白尿所致慢性肾衰竭的新靶点,2006年湛江市科技招标项目—重大疾病防治,承担者,结题,资助5万元。 [14]拉米夫定对成人乙肝病毒相关性肾炎治疗价值的研究,广东省医学科学技术研究基金,编号: A200548,承担者,在研, 资助1万元。 [15] 慢性肾衰基本方对人类肾小管上皮细胞表型转化及细胞外基质分泌的影响,2003年广东省中医药局项目,编号103073,承担者,已结题。 [16] 尿白细胞介素18水平对狼疮性肾炎肾组织活动指数评估价值的研究,2002年广东省高教厅项目,编号:Z02043,承担者,已结题。 [147] IL-1β转换酶抑制剂对狼疮性肾炎小鼠模型的治疗作用及机制的研究,2003年湛江市科技招标项目—重大疾病防治,承担者,已结题,资助5万元。 [18] 方格星虫粗提物肾保护作用初步研究及其有效成份初筛, 2006年湛江市科技招标项目—重大疾病防治,承担者,已结题,资助5万元。市厅级 (二)已发表SCI收录论文 [1] Liu WJ, Luo MN, Tan J, Chen W, Huang LZ, Yang C, Pan Q, Li B, Liu HF(刘华锋,通讯作者). Autophagy activation reduces renal tubular injury induced by urinary proteins, Autophagy, 2014, 10(2):243-256.(影响因子11.45) [2] Liu WJ, Xu BH, Ye L, Liang D, Wu HL, Zheng YY, Deng JK, Li B, Liu HF(刘华锋,通讯作者). Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells. Am J Physiol Renal Physiol, 2015, 308(6):F639-649. [3] Liu WJ, Shen TT, Chen RH, Wu HL, Wang YJ, Deng JK, Chen QH, Pan Q, Huang Fu C, Tao JL, Liang D, Liu HF(刘华锋,通讯作者)..Autophagy-lysosome pathway in renal tubular epithelial cells is disrupted by advanced glycation end products in diabetic nephropathy. J Biol Chem, 2015 14,290(33):20499-510. [4] Pan Q, Li YN, Ye L, Deng ZZ, Li L, Feng YM, Liu WJ, Liu HF(刘华锋,通讯作者). Geographical distribution, a risk factor for the incidence of lupus nephritis in China. BMC nephrology, 2014, 15:67 [5] Yu XX, Yao CW, Tao JL, Yang C, Luo MN, Li SM, Liu HF(刘华锋,通讯作者).The expression of renal Epstein?Barr virus markers in patients with lupus nephritis. Exp Ther med, 2014, 7(5):1135-1140. [6] Pan Q, Deng ZZ, Li L, Feng YM, Li YN, Liu HF(刘华锋,通讯作者). Effects of red blood cell lysing solutions on the detection of peripheral basophils of healthy normals and SLE patients by flow cytometry. J Immunoassay Immunochem, 2014, 35(4):368-77. [7] Pan QJ, Liu Y, Zhu XZ, Liu HF(刘华锋,通讯作者). Chloral hydrate-dependent decrease in peptidoglycan-induced inflammatory macrophage response is associated with lower expression of toll-like receptor . Exp Ther Med ;7(5):1305-1310. [8] Luo MN, Yao CW, Xu BH, Xu YZ, Liu WJ, Feng YM, Tao JL, Liu HF(刘华锋,通讯作者). Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy. experimental and Therapcutic medicine, 2014,7(3):553-559 [9] Pan Q, Wu J, Tao J, Chen Y, Li L, Deng Z, Liu W, Liu H(刘华锋,通讯作者). Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review. Exp Ther Med. 2014, (4):1027-1031. [10] Tang R, Yang C, Tao JL, Liu HF(刘华锋,通讯作者). Epithelial-mesenchymal of renal tubular epithelial cells induced by urine proteins requires the activation of PKC-α and βI isoenzymes. Cell Biol Int, 2011, 35(9):953-9. [11] Zhang HL, Xu ZC, Tan DS, Linag D, Liu HF(刘华锋,通讯作者). Seasonal distribution of active systemic lupus erythematosus and its correlation with meteorological factors. Clinics, 2011, 66(6):1-5. [12] Pan Q, Gao C, Chen Y, Feng Y, Liu WJ, Liu HF(刘华锋,通讯作者). Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target. Biomed Pharmacother. 2015,71:190-193. Review. [13] Liu HF(刘华锋,通讯作者), Guo LQ, Huang YY, et al. Thiazolidinedione attenuate proteinuria and glomerulosclerosis in Adriamycin-induced nephropathy rats via slit diaphragm protection. Nephrology, 2010, 5(1):75-83. [14] Liang D, Liu HF(刘华锋,通讯作者), Liu HY, et al. Effect of interleukin 18 on injury and activation of human proximal tubular epithelial cell. Nephrology, 2007, 12(1): 53-7. [15] Liang D, Ma W, Yao C, Liu H(刘华锋,通讯作者), Chen X. Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis. Cell Mol Immunol, 2006, 3(4):303-6. [16] Liu HF(刘华锋,通讯作者), Liang D, Wang LM, Zhou N, Yao CW, Hong T, Tang DS, Chen XW.. Effects of specific interleukin-1beta-converting enzyme inhibitor on ischemic acute renal failure in murine models. Acta Pharmacol Sin, 2005, 26(11):1345-51. [17] Pan Q, Lan Q, Chen Y, Wu J, Tang P, Chen Q, Xie T, Wu P, Liu H (通讯作者:刘华锋). Dual function of IgG4 in the development of rheumatoid arthritis: A novel therapeutic target. J Inflamm,2015, Accepted. [18] Yang X, Chen C, Tian J, Zha Y, Xiong Y, Sun Z, Chen P, Li J, Yang T, Ma C,Liu H(刘华锋), Wang X, Hou FF. Urinary Angiotensinogen Level Predicts AKI in Acute Decompensated Heart Failure: A Prospective, Two-Stage Study. J Am Soc Nephrol. 2015 Feb 26. [19] Chen C, Yang X, Lei Y, Zha Y, Liu H(刘华锋), Ma C, Tian J, Chen P, Yang T6, Hou FF(侯凡凡). 2016 Aug 18.Urinary Biomarkers at the Time of AKI Diagnosis as Predictors of Progression of AKI among Patients with Acute Cardiorenal Syndrome. Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1536-44. [20] Pan Q, Gao C, Chen Y, Feng Y, Liu WJ, Liu HF(通讯作者:刘华锋). Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target. Biomed Pharmacother. 2015, 71:190-3. [21] You YK, Huang XR, Chen HY, Lyu XF , Liu HF(共同通讯作者:刘华锋), Lan HY. C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway. Sci Rep, 2016, 6:26740. [22] Pan QJ, Cai J, Peng Y, Xiao HY, Zhang LF, Chen JY, Liu HF(通讯作者:刘华锋). Protective effect of a novel antibody against TLR2 on zymosan-induced acute peritonitis in NF-κB transgenic mice. Am J Transl Res, 2017, 9(2):XXX-XXX [23] Wei Jing Liu WJ, Ye L, Huang WF, Guo LJ, Xu ZG, Wu HL, Yang C, Liu HF(通讯作者:刘华锋). p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation. Cell Mol Biol Lett, Cell Mol Biol Lett, 2016,21:29 [24] Pan QJ, Li Gong L, HY, Feng YM, Li L, Deng ZZ, Ling Ye L, Zheng J, Dickerson CA, Ye L, An N, Yang C, Liu HF(通讯作者:刘华锋). Basophil activation-dependent autoantibody and IL-17 production exacerbate systemic lupus erythematosus. Front Immunol,(accepted) . [25] Liu WJ, ZH Li, Chen XC, Zhao XL, Zhong Z, Yang C, Wu H, An N, Li WY, Liu HF(通讯作者:刘华锋). Lysosomal dysfunction blocked autophagic pathway contributes to C5b-9 induced podocyte injury in idiopathic membranous nephropathy. Sci Rep,(accepted). (三)主编专著 [1] 陈孝文,刘华锋,主编. 急性肾衰竭(第2版). 北京, 人民卫生出版社, ISBN:9787117125987. 2010. [2] 陈孝文,梁东, 刘华锋,主编. 慢性肾衰竭. 北京, 中国医药科技出版社, ISBN:9787506734462. 2006. (四)省级及国家级科研成果奖 [1] 白细胞介素-18及其相关因子在人类慢性肾脏疾病作用的研究获2006年度广东省科学技术奖三等奖(刘华锋为第一完成人) [2] “粤西地区肾脏病理诊断平台的建设以及推广应用”获 2011年度广东省科技学技术奖三等奖(刘华锋为第一完成人) [3] “慢性肾小管-间质损伤发生机制及中西结合防治系列研究”获 2012年度广东省科学技术奖三等奖(刘华锋为第一完成人) [4] 慢性肾脏病的发病机制及综合防治系列研究,2016年度广东省科学技术奖三等奖。(刘华锋为第2完成人) [5] 侯凡凡,--,刘华锋,--等。慢性肾脏病进展的机制及临床防治研究,2016年国家科学技术奖二等奖。(刘华锋为第12完成人) ... 更多 |
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