特邀嘉宾
Aleem Siddiqu 教授
加利福尼亚大学,美国
更新时间:2017/5/5 10:25:41
Aleem Siddiqui is currently a Professor in the Division of Infectious Diseases, Department of Medicine, at the University of California, San Diego. He received his undergraduate and graduate education from Osmania University, Hyderabad, India and Ph.D., degree from the University of Kansas Medical Center, Kansas City, KS. He was a postdoctoral fellow at the University of Colorado Medical School, Denver, CO with Dr. Ray Erikson followed by a second postdoctoral fellowship with Dr. William S Robinson at Stanford University, CA. He was instrumental in the first molecular cloning of an infectious Hepatitis B virus (HBV) DNA at Stanford University in the laboratory of Dr. Stan Cohen in 1979. He then joined the University of Colorado Medical School as an Assistant Professor. He moved to the University of California, San Diego in 2005. His current research focuses on molecular mechanisms of liver disease pathogenesis associated with HBV and HCV viral infections. More recent work is related to mitochondrial dynamics and metabolisms and innate immunity during HBV/HCV infections. The work shows that HBV/HCV-induced mitophagy triggers events that suppress innate immunity via massive ubiquitination of MAVS, a key player in interferon synthesis. He is currently editorial member of several journals including Journal of Biological Chemistry, and also serves as an Associate editor of PLoS Pathogens.