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李小兵:烧伤合并肺挫伤复苏液体治疗的实验研究 PPT讲座视频 中华医学会烧伤外科学分会2017年学术年会暨第二十五届全军烧伤外科学专业学术会议
标题: 烧伤合并肺挫伤复苏液体治疗的实验研究
讲者: 李小兵
单位: 天津市第一中心医院
播放: 861
论文摘要: Background:
The present study aims to evaluate the effectiveness of different treatment regimens on combined injury -induced lung injury.
Methods:
Rabbits were subjected to non-lethal closed-chest bilateral lung contusion followed by a 30% total body surface area scald burn. The rabbits were randomly assigned to resuscitation groups that maintained a minimum mean arterial blood pressure of 70 mmHg with one of three methods: normal saline plus polygeline injection in a ratio of 1:1 (1:1G), normal saline plus polygeline injection in a ratio of 1:2 (1:2G), normal saline plus polygeline injection in a ratio of 1:3 (1:3G), After injury, lung injury was assessed using lung wet-to-dry (W/D) weight ratio, ELISA, and real-time PCR analysis.
Results:
 In 1:3 fluid resuscitation group, Rabbits exhibited significantly reduced lung W/D ratio, alveolar hemorrhage, MPO activity and IL-8 and TNF-α levels in serum compared with 1:1 fluid resuscitation group or 1:2 fluid resuscitation group. 1:3 fluid resuscitation-treated rabbits attenuated also attenuated ultrastructural changes in lung at 24 hours after combined injury.
Conclusions:
This study demonstrated the impact of fluid resuscitation on combined injury-induced lung injury. Further, 1:3 fluid resuscitation treatment at the early stage of lung injury after combined lung contusion and burn injury is more effective.
 
 

整形与烧伤外科

天津市第一中心医院

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