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黄雨晴:Circulating miR92a expression level is a potential marker of atherosclerosis in patients with essential hypertension PPT讲座视频 2016年中国高血压年会暨第18届国际高血压及相关疾病学术研讨会
标题: Circulating miR92a expression level is a potential marker of atherosclerosis in patients with essential hypertension
讲者: 黄雨晴
单位: 广东省人民医院
播放: 4685
论文摘要: Abstract:Objectives:MicroRNAs
(miRs) are key post-transcriptional regulators of gene expression in all
eukaryotic cells, and play a vital role in the evolution of hypertension and
cardiovascular remodeling, and therefore, have emerged as potential biomarkers for
cardiovascular disease.
Methods:We assessed
240 participants including 60 healthy volunteers with normal carotid
intima-media thickness (nCIMT), 60 healthy volunteers with increased CIMT (iCIMT),
60 hypertension patients with nCIMT and 60 hypertension patients with iCIMT.
All patients underwent measurements of CIMT, carotid-femoral pulse wave
velocity (cfPWV) and ambulatory blood pressure (BP) monitoring. Plasma miR-92a
expression was quantified by real-time reverse transcription polymerase chain
reaction. Correlations between miR-92a expression and BP parameters, CIMT and
cfPWV were assessed using the Spearman correlation coefficient.
Results:We
observed the lowest miR-92a expression (24.59±1.30vs27.76±2.13vs29.29±1.89
vs33.76±2.08;
p<0.001) in healthy controls with nCIMT, followed by healthy controls with
iCIMT, then hypertension patients with nCIMT and highest expression in
hypertension patients with iCIMT. Additionally, MiR-92a levels showed a significant
positive correlation with 24-h mean systolic BP (r=0.807, p<0.001), 24-h
mean diastolic BP (r=0.649, p<0.001), 24-h mean pulse pressure (r=0.697,
p<0.001), 24-h daytime pulse pressure (r=0.654, p<0.001), 24-h nighttime
pulse pressure (r=0.573, p<0.001), CIMT (r=0.571,p<0.001) and cfPWV (r=0.601,
p<0.001).
Conclusion:
Our data present significant evidence that circulating miR-92a represents a
potential non-invasive atherosclerosis marker in essential hypertensive
patients.

心血管内科

广东省人民医院

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