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北京大学第三医院
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Study on relationship with blood routine, coagulation function and disease activity in IBD children ZHANG JUAN, LI ZAILING* Objective: The coagulation mechanism of IBD patients may be disturbed due to inflammation, causing bleeding or thrombosis. To investigate the changes of blood routine and coagulation function in children with IBD and their relationship with disease activity.Methods: Clinical data of children diagnosed with CD or UC from January 2009 to March 2018 in Department of pediatric of Peking University Third Hospital were reviewed. The following laboratory parameters were determined: WBC, hematocrit, platelet count, fibrinogen, partial activated thromboplastin time, C-reactive protein (CRP), and albumin. (ALB) and coagulation function (prothrombin time, prothrombin activity A, fibrinogen, activated partial thromboplastin time, thromboplastin time, D-dimer). The PCDAI>30 score is defined as medium and severe CD, and PUCAI>35 score is defined as moderate and severe UC. Compare whether there are some differences in the above indicators between UC and CD and disease activity of IBD. Results: a total of 28 children were enrolled in this study, including 15 males and 13 females. The median age of diagnosis was 2.5 years(2 month-13 year). There were 16 cases of Crohn's disease (CD) and 12 cases of ulcerative colitis (UC). PCDAI was 41.25 points (12.5-72), mild activity in 3 cases, moderate and severe activities in 13 cases. PUCAI was 32.5 (15-80), mild activity in 6 cases, moderate and severe activity in 6 cases. It was found that ALB in CD group(33.85 ± 6.57 g/L vs 38.87 ± 6.26 g/L, P=0.034) was lower than that in UC group, CRP was higher than UC group (P=0.034). There was no difference in laboratory parameters in UC patients with different disease activity. In CD patients the WBC (14.86±4.76^109/L vs 6.55±0.84^109/L, P=0.011) and CRP (3.87±3.11 mg/dl vs 0.82±0.63 mg/dl, P=0.006) were significantly higher than those in the mild activity group, and ALB (32.22± 6.17 vs 40.97±1.27,P=0.000) was significantly lower than the mild activity group. Prothrombin time（12.02±1.28s vs 10.76±0.73s，P=0.076）and D-Dimer (0.32±0.25 vs 0.12±0.02, P=0.051) was higher than that in mild activity group, but no statistical difference was found. The D-Dimer level of children with moderate or severe CD was significantly higher than that of moderate and severe UC (0.32±0.25 ug/ml vs 0.06±0.01 ug/ml, P=0.016). Conclusion: White blood cells count, CRP and ALB can be used as predictors of disease activity in children with CD. CD is more prone to hypercoagulability than children with UC. ... 更多 |
l Antibiotic prescribing and antibiotic resistances of common pathogens in Chinese children.
作者： 杨永弘
单位： 首都医科大学附属北京儿童医院
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